Journal
ORGANIC LETTERS
Volume 14, Issue 7, Pages 1764-1767Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol300359s
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- Syracuse University
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A facile synthesis of imidazo[4,5-b]pyridines and -pyrazines is described using a Pd-catalyzed amide coupling reaction. This reaction provides quick access to products with substitution at N1 and C2. A model system relevant to the natural product pentosidine has been demonstrated, as well as the total synthesis of the mutagen 1-Me-5-PhIP.
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