4.8 Article

Efficient Construction of Fused Indolines with a 2-Quaternary Center via an Intramolecular Heck Reaction with a Low Catalyst Loading

Journal

ORGANIC LETTERS
Volume 14, Issue 8, Pages 2066-2069

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol300584m

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Funding

  1. State Key Laboratory of Natural Medicines [JKGZ201110]
  2. Fundamental Research Funds for the Central Universities [JKZ2009002]
  3. [NCET-2008]
  4. [PCSIRT-IRT1193]

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An efficient construction of fused indolines with a 2-quaternary center through a palladium-catalyzed intramolecular Heck reaction of N-(2(2-halobenzoxyl)-2,3-disubstituted indoles is disclosed. This protocol provided a straightforward access to diverse fused indolines with good functional group tolerance.

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