Journal
ORGANIC LETTERS
Volume 14, Issue 19, Pages 4979-4981Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol3022726
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- NIH NIGMS [GM-073836]
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A mild and practical protocol for the copper-mediated trifluoromethylation of aryl and heteroaryl boronic acids using NaSO2CF3 (Langlois' reagent) and TBHP is described. The reaction proceeds at room temperature under ambient conditions, and the products can be readily purified by extraction or column chromatography.
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