SelEXSIDE: Fast and Easy Measurement of Multiple-Bond 1H,13C Coupling Constants for Stereochemical Analysis

Long-range H-1,C-13 coupling constants ((n)J(CH)) are underutilized parameters for stereochemical structure determination, primarily because they are not easy to measure. This report describes a rapid and easily interpreted method for the measurement of one or more (n)J(CH) values based on a C-13 band-selective EXSIDE (SelEXSIDE), which reduces experiment times from many hours down to a few minutes while allowing a simple and straightforward readout of (n)J(CH) values from the resulting in-phase doublet signal.