Journal
ORGANIC LETTERS
Volume 14, Issue 15, Pages 3878-3881Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol301607q
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Funding
- Fogarty International Center (FIC) International Cooperative Biodiversity Group (ICBG) [U01 TW006634]
- FIC [K01 TW008002]
- Panamanian Ministry of Science (SENACYT) [EST07-030B]
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Four unsaturated polyketide lactone derivatives, coibacins A-D, were isolated from a Panamanian marine cyanobacterium, cf. Oscillatorla sp. The two different types of termini observed in these co-occurring metabolites, either a methyl cyclopropyl ring as seen in curacin A or a methyl vinyl chloride similar to that observed in the jamaicamides, suggest an intriguing flexibility in the beta branch forming biosynthetic process. The coibacins possess selective antileishmanial activity as well as potent anti-inflammatory activity.
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