4.8 Article

Copper(I)-Catalyzed Cascade Dearomatization of 2-Substituted Tryptophols with Arylidonium Salts

Journal

ORGANIC LETTERS
Volume 14, Issue 17, Pages 4525-4527

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol301939w

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Funding

  1. National Basic Research Program of China (973 Program) [2009CB825300]
  2. National Natural Science Foundation of China [21025209, 20932008, 21102160, 21121062]

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Copper(I)-catalyzed dearomative arylation and vinylation of 2-substituted tryptophols were realized with a subsequent cyclization reaction. The cascade dearomatization sequence provided versatile furoindoline derivatives with two quaternary carbon centers in good to excellent yields.

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