4.8 Article

Parallel Microflow Photochemistry: Process Optimization, Scale-up, and Library Synthesis

Journal

ORGANIC LETTERS
Volume 14, Issue 17, Pages 4342-4345

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol301773r

Keywords

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Funding

  1. Environmental Protection Agency (EPA) [2008-ET-MS-2-S2]
  2. Department of Environment, Heritage and Local Government (DEHLG) [2008-S-ET-2]
  3. Environmental Protection Agency Ireland (EPA) [2008-S-ET-2, 2008-ET-MS-2-S2] Funding Source: Environmental Protection Agency Ireland (EPA)

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A novel, multimicrocapillary flow reactor (M mu CFR) was constructed and applied to a series of sensitized photoadditions involving 2(5H)-furanones. The reactor allowed for rapid and energy-, time-, and space-efficient sensitizer screening, process optimization, validation, scale-up, and library synthesis.

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