Journal
ORGANIC LETTERS
Volume 14, Issue 6, Pages 1640-1643Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol300428q
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Funding
- NIH [GM095666, RR08389-01]
- Beckman Foundation
- Research Corporation
- Sloan Foundation
- NSF [CHE-9208463, CHE-9629688]
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Structurally novel endoperoxides can be sythesized by the photocatalytic cyclotrimerization of bis(styrene) substrates with molecular oxygen. The optimal catalyst for this process is Ru(bpz)(3)(2+), which is a markedly more efficient catalyst for these photooxygention reactions than conventional organic photosensitizers. The 1,2-dioxolane products are amenable to synthetic manipulation and can be easily processed to 1,4-diols and gamma-hydroxyketones. An initial screen of the biological activity of these compounds reveals promising inhibition of cancer cell growth.
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