Journal
ORGANIC LETTERS
Volume 14, Issue 22, Pages 5808-5810Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol3024665
Keywords
-
Categories
Funding
- NIH [S10 RR019022]
- Department of Pharmacology
- William K. Warren, Jr. Funding
Ask authors/readers for more resources
The first total synthesis of Aplidiopsamine A, a rare 3H-pyrrolo[2,3-c]quinoline alkaloid from the Aplidiopsis confluata, has been achieved following the proposed biosynthesis. This biomimetic synthesis requires only five steps and proceeds in 20.8% overall yield. Biological evaluation across large panels of discrete molecular targets identified that Aplidiopsamine A is a highly selective PDE4 inhibitor, a target for numerous CNS disorders.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available