4.8 Article

Ir(I)-Catalyzed Intermolecular Regio- and Enantioselective Hydroamination of Alkenes with Heteroaromatic Amines

Journal

ORGANIC LETTERS
Volume 14, Issue 3, Pages 780-783

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol203318z

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Funding

  1. MEXT, Japan
  2. Waseda University, Japan

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A cationic Ir(I)-C-3-TUNEPHOS complex catalyzed an intermolecular hydroamination of styrene derivatives with various heteroaromatic amines. The reaction gave Markovnikov products with perfect regioselectivity and good enantioselectivity under solvent-free conditions.

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