Journal
ORGANIC LETTERS
Volume 14, Issue 20, Pages 5370-5373Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol302593z
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Funding
- Daiichi-Sankyo Co., Ltd.
- Grants-in-Aid for Scientific Research [23790016] Funding Source: KAKEN
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The high utility of 2,4,6-trichlorophenyl formate, a highly reactive and easily accessible crystalline CO surrogate, is demonstrated. The decarbonylation with NEt3 to generate CO proceeded rapidly at rt, thereby allowing external-CO-free Pd-catalyzed carbonylation of aryl/alkenyl halides and triflates. The high reactivity of the CO surrogate enabled carbonylation at rt and significantly reduced the quantities of formate to near-stoichiometric levels. The obtained trichlorophenyl esters can be readily converted to a variety of carboxylic acid derivatives in high yields.
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