Journal
ORGANIC LETTERS
Volume 14, Issue 13, Pages 3280-3283Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol301130u
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Funding
- National Basic Research Program of China (973 Program) [2009CB825300]
- National Science Foundation of China [20872003]
- State Key Laboratory of Drug Research
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A copper-catalyzed aerobic oxidative cross-dehydrogenative coupling (CDC) of amine with alpha-carbonyl aldehyde has been developed. Many types of amines are tolerant in this transformation leading to various alpha-ketoamides compounds. Wide substrate scope, CDC strategy and using air as oxidant make this transformation highly efficient and practical. Molecular oxygen acts not only as the oxidant, but also as an initiator to trigger this catalytic process. Furthermore, mechanism studies show that carbonyl group of a-carbonyl aldehyde plays a role as the directing group to facilitate this chemical process.
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