4.8 Article

CuI/DMPAO-Catalyzed N-Arylation of Acyclic Secondary Amines

Journal

ORGANIC LETTERS
Volume 14, Issue 12, Pages 3056-3059

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol301135c

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Funding

  1. Chinese Academy of Sciences, National Natural Science Foundation of China

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DMPAO has been found to be a powerful ligand to enable copper-catalyzed coupling of aryl halides with aliphatic acyclic secondary amines take place under relatively mild conditions, and coupling of aryl halides with primary amines and cyclic secondary amines proceeds at low catalyst loading.

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