Journal
ORGANIC LETTERS
Volume 14, Issue 23, Pages 6068-6071Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol302955u
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Funding
- Natural Science Foundation of China [21042007, 21172162]
- Young National Natural Science Foundation of China [21202111]
- Young Natural Science Foundation of Jiangsu Province [BK2012174]
- PAPD
- Soochow University
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A novel CuI/BF3 center dot Et2O/O-2-mediated reaction utilizing ketones and benzylamines for the construction of substituted imidazoles in one step under mild conditions has been demonstrated. This protocol involved the removal of eight hydrogen atoms, the functionalization of four C(sp(3))-H bonds and three new C-N bond formations.
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