4.8 Article

A Naphthalimide-Based Glyoxal Hydrazone for Selective Fluorescence Turn-On Sensing of Cys and Hcy

Journal

ORGANIC LETTERS
Volume 14, Issue 2, Pages 520-523

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol203123t

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Funding

  1. Natural Science Foundation of China (NSFC) [21172137, 21072121]

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A fluorescent turn-on probe for Cys/Hcy based on inhibiting the C=N isomerization quenching process by an intramolecular hydrogen bond was reported. The probe exhibited higher selectivity toward Cys/Hcy over other amino acids as well as thiol-containing compounds.

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