4.8 Article

Reaction Based Fluorescent Probes for Hydrogen Sulfide

Journal

ORGANIC LETTERS
Volume 14, Issue 8, Pages 2184-2187

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol3008183

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Funding

  1. NSF [0844931]
  2. NIH [R01HL088559]
  3. Direct For Mathematical & Physical Scien
  4. Division Of Chemistry [0844931] Funding Source: National Science Foundation

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A reaction based fluorescence turn-on strategy for hydrogen sulfide (H2S) was developed. This strategy was based on a H2S-specific Michael addition-cyclization sequence. Other biological thiols such as cysteine and glutathione did not pursue the reaction and therefore did not turn on the fluorescence/consume the substrates. The probes showed good selectivity and sensitivity for hydrogen sulfide.

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