Journal
ORGANIC LETTERS
Volume 15, Issue 1, Pages 10-13Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol302814x
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Funding
- MOST of China [2009CB825300]
- NSFC [20925207, 21002001]
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The first palladium-catalyzed ortho-trifluoromethylation of the aromatic C-H bond directed by an acetamino group is reported. This method provides an efficient and green approach to synthesize the highly biological potential key structure of ortho-CF3 acetanilides and anilines.
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