Journal
ORGANIC LETTERS
Volume 14, Issue 2, Pages 490-493Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol203081x
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Funding
- National Natural Science Foundation of China [20802074]
- National Basic Research Program of China (973 Program) [2010CB833300]
- Sichuan Youth Science and Technology Foundation
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An efficient and stereoselective reaction between 3-isothiocyanato oxindoles and isatins/isatinimines has been developed to afford structurally diverse dispiro[oxazolidine-2-thione]bisoxindoles and dispiro[imidazolidine-2-thione]bisoxindoles in excellent results under mild conditions. The potential of asymmetric induction by means of a chiral auxiliary was explored. The isomers are separable, and products could be isolated as single diastereomers by column chromatography. Further synthetic transformations of the reaction product were also successfully realized.
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