Journal
ORGANIC LETTERS
Volume 14, Issue 6, Pages 1496-1499Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol300235k
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- CNRS
- ANR [ANR-10-LABX-33]
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An efficient and practical decarboxylative cross-coupling reaction of quinolin-4(1H)-one 3-carboxylic acids with (hetero)aryl halides has been established. Under a bimetallic system of PdBr2 and silver carbonate, the protocol proved to be general, and a variety of 3-(hetero)aryl 4-quinolinones and related heterocycles, such as 3-aryl-1,8-naphthyridin-4(1H)-ones, 3-arylcoumarins, 3-arylquinolin-2(1H)-ones, and 2-arylchromones, can be prepared in good to excellent yields.
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