Journal
ORGANIC LETTERS
Volume 14, Issue 17, Pages 4370-4373Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol301831k
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Funding
- David and Lucille Packard Foundation
- Searle Scholars Program
- Yale University
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We show that a broad range of aryl iodides are efficiently coupled with secondary phosphine oxides using 1 mol % of a catalyst formed in situ from tris(dibenzylideneacetone)dipalladium and Xantphos (1). Scalemic (S)-methylphenylphosphine oxide [(S)-2e] is shown to undergo arylation without detectable stereoerosion. The application of this method to the synthesis of novel P-chiral phosphines and PCP ligands is demonstrated.
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