Journal
ORGANIC LETTERS
Volume 14, Issue 4, Pages 992-995Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol2032653
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- CNR [PM.P01.020.002]
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Structural similarity or even the identity of polyketide compounds does not necessarily imply unique biosynthesis. Feeding experiments with a C-13 labeled precursor establish that the C-3 units in 7-methyl-cyercene-1 (1) are derived from intact propionate in the marine mollusc Ercolania funerea. The same compound in the terrestrial fungus Leptosphaeria maculans/Phoma lingam is synthesized by an acetate/SAM pathway thus proving for the first time metabolic convergence of polyketide biosynthesis in eukaryotes. Traditional H-1-C-13 NMR correlation spectroscopy has been successfully applied to estimate C-13 incorporation in biosynthetic experiments.
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