Journal
ORGANIC LETTERS
Volume 14, Issue 15, Pages 3966-3969Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol3017287
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Funding
- Swedish Research Council (VR)
- Knut och Alice Wallenbergs Foundation via the Center of Molecular Catalysis at Stockholm University (CMCSU)
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A copper-mediated trifluoromethylation of propargylic halides and trifluoroacetates was performed with high allenyl or propargyl selectivity. The reaction proceeds smoothly with aliphatic and aromatic substituents bearing either electron-withdrawing or -supplying groups. Preliminary mechanistic results indicate an ionic mechanism involving nucleophilic transfer of the CF3 group from the Cu complex to the propargylic substrate.
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