Journal
ORGANIC LETTERS
Volume 14, Issue 13, Pages 3352-3355Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol3013342
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Funding
- Chinese NSF [2097209, 21172140]
- Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning, Shanghai Education Committee [10YZ04]
- Shanghai Leading Academic Discipline Project [S30107]
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A room-temperature Ni-catalyzed reductive method for the coupling of aryl bromides with secondary alkyl bromides has been developed, providing C(sp(2))-C(sp(3)) products in good to excellent yields. Slight modification of this protocol allows efficient coupling of activated aryl chlorides with cyclohexyl bromide and aryl bromides with allylic acetate.
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