Journal
ORGANIC LETTERS
Volume 14, Issue 14, Pages 3668-3671Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol301515d
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Funding
- MINECO [CTQ2008-00947/BQU, NSF Quimica 1026553]
- DEC [2009SGR623]
- ICIQ foundation
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A chemically modified, first generation MacMillan imidazolidin-4-one has been anchored onto 1% DVB Merrifield resin and Fe3O4 (5.3 +/- 1.4 nm) magnetic nanoparticles through copper-catalyzed alkyne azide cycloaddition (CuAAC) reactions. The resulting immobilized catalysts have been successfully used in the asymmetric Friedel-Crafts alkylation of N-substituted pyrroles with alpha,beta-unsaturated aldehydes. The PS-supported catalyst (B) showed higher catalytic activity and enantioselectivity, while the MNP-supported one (A) showed higher recyclability and could be used in a sequential process with intermediate magnetic decantation.
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