4.8 Article

Multicomponent Approach in the Synthesis of 2,2,6-Trisubstituted Morpholine Derivatives

Journal

ORGANIC LETTERS
Volume 14, Issue 20, Pages 5250-5253

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol3024105

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Funding

  1. National University of Singapore [143-000-509-112]
  2. NUS

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An efficient synthesis of 2,2,6-trisubstituted morpholine is described which involves a multicomponent process by simply mixing epichlorohydrin, N-bromosuccinimide, nosyl amide, and an olefin. The products contain chloride handles which are suitable for further modification.

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