Journal
ORGANIC LETTERS
Volume 14, Issue 10, Pages 2622-2625Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol300958c
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Funding
- Japan Society for the Promotion of Science [23390002, 23659001, 23790002]
- Ministry of Education, Culture, Sports, Science and Technology, Japan [23390002]
- Grants-in-Aid for Scientific Research [23659001, 23390002, 23790002] Funding Source: KAKEN
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In this study, a facile synthesis of 3-carboxylated indoles involving a tandem-type cyclization of 2-ethynylanilines and subsequent CO2 fixation at the 3-position of the indole ring is realized. The reaction proceeds efficiently at 65 degrees C under 10 atm of CO2, giving rise to variously substituted 3-carboxylated indoles, generally in high yields. An inorganic base, such as K2CO3, is the only reagent required, and the addition of transition metal catalysts is not necessary. The method provides a novel, simple, and promising strategy for CO2 fixation in the research field of heterocyclic chemistry.
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