4.8 Article

Rhodium-Catalyzed Synthesis of Branched Amines by Direct Addition of Benzamides to Imines

Journal

ORGANIC LETTERS
Volume 14, Issue 9, Pages 2304-2307

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol300723x

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Funding

  1. NIH [GM069559]
  2. Office of Energy Research, Office of Basic Energy Sciences, Chemical Sciences Division, U.S. Department of Energy [DE-AC02-05CH11231]
  3. National Sciences and Engineering Research Council of Canada (NSERC)

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Rhodium-catalyzed addition of benzamide C-H bonds to a range of aromatic N-sulfonyl aldimines has been developed and proceeds with high functional group compatibility. The synthetic utility of the resulting branched amine products has also been demonstrated by the preparation of isoindoline and isoindolinone frameworks.

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