4.8 Article

Cobalt-Catalyzed Ortho-Arylation of Aromatic Imines with Aryl Chlorides

Journal

ORGANIC LETTERS
Volume 14, Issue 16, Pages 4234-4237

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol301934y

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Funding

  1. Singapore National Research Foundation [NRF-RF2009-05]
  2. Nanyang Technological University
  3. JST, CREST

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An ortho-arylation reaction of aromatic imines with aryl chlorides has been achieved using a cobalt N-heterocyclic carbene catalyst in combination with a neopentyl Grignard reagent. The reaction takes place at room temperature to afford biaryl products in moderate to good yields.

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