4.8 Article

Facile Synthesis of 3a,6a-Dihydro-furo[2,3-b]furans and Polysubstituted Furans Involving Dearomatization of Furan Ring via Electrocyclic Ring-Closure

Journal

ORGANIC LETTERS
Volume 14, Issue 2, Pages 616-619

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol203232m

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Funding

  1. NSF of China [21072062]
  2. Fundamental Research Funds for the Central Universities [2012ZZ0043]
  3. Natural Science Foundation of Guangdong Province, China [10351064101000000]

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A facile and atom-economic method for the synthesis of 3a,6a-dihydro-furo[2,3-b]furan derivatives and polysubstituted furans starting from furylcarbionls has been developed. This protocol involved a domino Claisen rearrangement/dearomatizing electrocyclic ring-closure/aromatizing electrocyclic ring-opening sequence.

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