4.8 Article

Regioselective Enzymatic Carboxylation of Phenols and Hydroxystyrene Derivatives

Journal

ORGANIC LETTERS
Volume 14, Issue 8, Pages 1974-1977

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol300385k

Keywords

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Funding

  1. FFG-COMET
  2. DK Molecular Enzymology [W9]
  3. FWF
  4. BMWFJ
  5. BMVIT
  6. SFG
  7. Standortagentur Tirol
  8. ZIT
  9. Austrian Science Fund (FWF) [W 901] Funding Source: researchfish

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The enzymatic carboxylation of phenol and styrene derivatives using (de)carboxylases in carbonate buffer proceeded in a highly regioselective fashion: Benzoic acid (de)carboxylases selectively formed o-hydroxybenzoic acid derivatives, phenolic acid (de)carboxylases selectively acted at the beta-carbon atom of styrenes forming (E)-cinnamic acids.

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