4.8 Article

Pd-Catalyzed Imine Cyclization: Synthesis of Antimalarial Natural Products Aplidiopsamine A, Marinoquinoline A, and Their Potential Hybrid NCLite-M1

Journal

ORGANIC LETTERS
Volume 14, Issue 22, Pages 5804-5807

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol302676v

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Funding

  1. CSIR, New Delhi
  2. DST, New Delhi
  3. DST-SERC FAST-Track

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Palladium-catalyzed cyclization of imines has been developed to construct the extremely rare 3H-pyrrolo[2,3-c]quinoline ring system for diversity oriented first total synthesis of antimalarial marine natural product Aplidiopsamine A as well as synthesis of Marinoquinoline A and potential natural product hybrid NCLite-M1.

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