Journal
ORGANIC LETTERS
Volume 14, Issue 23, Pages 5880-5883Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol302790e
Keywords
-
Categories
Funding
- Swiss National Research Foundation [200020-126663]
- COST action D40 (SER) [C07.0097]
Ask authors/readers for more resources
A simple copper-catalyzed enantioselective synthesis of axially chiral chloroallenes from the propargylic dichlorides is reported, employing a catalytic amount of easily prepared SimplePhos ligand. Exclusive formation of the desired allenes was observed with good enantioselectivities (ee's 62-96%). Further transformations to trisubstituted allenes or terminal alkynes with a propargylic quaternary carbon center keep a high level of enantiopurity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available