Journal
ORGANIC LETTERS
Volume 14, Issue 24, Pages 6334-6337Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol303115v
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Funding
- KTH Royal Institute of Technology
- Lund University
- Estonian Science Foundation [7808]
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The use of asymmetric transfer hydrogenation combined with dynamic kinetic resolution for the synthesis of beta-hydroxy-alpha-(tert-butoxycarbonyl)-amino esters in water is described. This procedure provides the desired amino alcohols in good yields, diastereoselectivities, and enantioselectivities. A surfactant is employed to achieve good yields due to the hydrophobic nature of both the catalyst and substrate. The reaction setup is operationally simple, and nondegassed water can be used as the solvent.
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