Journal
ORGANIC LETTERS
Volume 14, Issue 24, Pages 6194-6197Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol302940y
Keywords
-
Categories
Funding
- 973 Program of China [2010CB833804]
- NSFC [21172204, 30973680, 30670219]
- 863 Program of China [2012AA092104, 2011AA09070106, SS2013AA090201]
- Special Fund for Marine Scientific Research in the Public Interest of China [2010418022-3]
- Innovation and Research Foundation of Ocean University of China [201261002]
Ask authors/readers for more resources
Fradcarbazoles A-C (1-3), three new indolocarbazoles, were isolated from a mutant strain of the marine-derived actinomycete Streptomyces fradiae 007M135. Their structures were established by spectroscopic analysis, quantum chemical calculation, CD spectra, and chemical transformation. Fradcarbazole A (1) possessed a unique skeleton consisting of a staurosporine core, a thiazole ring, and an indole fragment. Compounds 1-3 displayed significant cytotoxicity against HL-60, K562, A-549, and BEL-7402 cell lines and inhibitory effects on the kinase PKC-alpha. with IC50 values of 0.001-4.58 mu M.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
