Journal
ORGANIC LETTERS
Volume 14, Issue 24, Pages 6342-6345Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol303122w
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Funding
- World Premier International Research Center Initiative (WPI), MEXT, Japan
- MEXT of Japan [22380067, 23688014, 24110505]
- Grants-in-Aid for Scientific Research [23688014, 22380067, 24110505] Funding Source: KAKEN
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The pentasaccharide part of the potent neuritogenic ganglioside GAA-7 has been synthesized for the first time. The unique branched terminus constituting partially modified sialic acids and N-acetylgalactosamine was successfully established by stereoselective double-sialylation using 8-O-methyl-N-Troc-sialic acid as a donor. The final 4 + 1 coupling reaction provided a high yield of pentasaccharide, which was deprotected to deliver the target molecule.
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