Journal
ORGANIC LETTERS
Volume 14, Issue 15, Pages 3894-3897Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol3016435
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Funding
- National Basic Research Program of China [2011CB936003]
- NSFC [21072169]
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An efficient synthesis of indolo[1,2-c]quinazoline derivatives has been developed by copper-catalyzed sequential Ullmann N-arylation and aerobic oxidative C-H amination. The protocol uses readily available 2-(2-halophenyl)-1H-Indoles and (aryl)methanamines as the starting materials to afford indolo[1,2-c]quinazolines, which are the core units of hinckdentine A.
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