4.8 Article

Rhodium-Catalyzed Asymmetric Coupling Reaction of Allylic Ethers with Arylboronic Acids

Journal

ORGANIC LETTERS
Volume 14, Issue 17, Pages 4502-4505

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol3019902

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Funding

  1. MEXT, Japan
  2. New Energy and Industrial Technology Development Organization (NEDO)
  3. Grants-in-Aid for Scientific Research [22550093] Funding Source: KAKEN

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An asymmetric allylic substitution of simple allylic ethers with arylboronic acids in the presence of a rhodium(I)/(R)-DTBM-SEGPHOS catalyst has been developed. The reactions proceeded smoothly at room temperature to give the corresponding branch products with excellent regioselectivities and good to excellent enantioselectivities.

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