Journal
ORGANIC LETTERS
Volume 14, Issue 6, Pages 1540-1543Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol300274u
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Funding
- Polish National Science Centre [N N204 145740]
- Foundation for Polish Science
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An organocatalytic Friedel-Crafts alkylation of indoles with alpha,beta-unsaturated ketones was found to be efficiently accelerated under high-pressure conditions with a low loading of chiral primary amine salts with good yield and enantioselectivity up to 90%. This approach also allows, for the first time, selected indole derivatives containing quaternary stereogenic centers to be obtained from prochiral beta,beta-disubstituted enones with an enantioselectivity up to 80%.
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