4.8 Article

Copper-Catalyzed Synthesis of Purine-Fused Polycyclics

Journal

ORGANIC LETTERS
Volume 14, Issue 17, Pages 4494-4497

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol301848v

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Funding

  1. National Natural Science Foundation of China [20802016, 21072047]
  2. Program for New Century Excellent Talents in University of Ministry of Education [NCET-09-0122]
  3. Excellent Youth Foundation of Henan Scientific Committee [114100510012]
  4. PIRT [2012IRTSTHN006]
  5. PCSIRT [IRT1061]
  6. Excellent Youth Program of Henan Normal University
  7. University of Birmingham

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A novel protocol for a Cu-catalyzed direct C-(sp2)-H activation/intramolecular amination reaction of 6-anilinopurine nucleosides has been developed. This approach provides a new access to a variety of multiheterocyclic compounds from purine compounds via Cu-catalyzed intramolecular N-H bond tautomerism which are endowed with fluorescence.

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