Journal
ORGANIC LETTERS
Volume 14, Issue 14, Pages 3776-3779Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol301666n
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- Netherlands Organization of Scientific Research (NWO)
- Top Institute Pharma (TIP)
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Well-defined fragments of hyaluronic acid (HA) have been obtained through a fully automated solid-phase oligosaccharide synthesis. Disaccharide building blocks, featuring a disarmed glucuronic acid donor moiety and a di-tert-butylsilylidene-protected glucosamine part, were used in the rapid and efficient assembly of HA fragments up to the pentadecamer level, equipped with a conjugation-ready anomeric allyl function.
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