Journal
ORGANIC LETTERS
Volume 14, Issue 9, Pages 2382-2385Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol3008028
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- Singapore National Research Foundation (NRF)
- Singapore Economic Development Board (EDB)
- GlaxoSmithKline (GSK)
- Nanyang Technological University (NTU)
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A diastereoselective access to beta-lactam fused spirocyclic oxindoles and related compounds bearing all carbon spiro centers is described. This N-heterocyclic carbene-catalyzed process employed challenging beta,beta-disubstituted alpha,beta-unsaturated imines to react with enals.
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