4.8 Article

Application of Dearomatization Strategy on the Synthesis of Furoquinolinone and Angelicin Derivatives

Journal

ORGANIC LETTERS
Volume 14, Issue 8, Pages 2114-2117

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol300648t

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Funding

  1. National Natural Science Foundation of China [21072033]

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The oxidative dearomatization of 3-(3-alkynyl-4-hydroxyphenyl)propanoic acid is combined with a cascade transition-metal catalyzed cyclization/addition/aromatization/lactamization sequence, which provides a novel approach to prepare furoquinolinone and angelicin derivatives in a convergent and efficient manner.

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