Journal
ORGANIC LETTERS
Volume 14, Issue 13, Pages 3474-3477Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol301442z
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Funding
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- Government of Ontario (ERA)
- Canadian Foundation for Innovation (CFI)
- Ontario Innovation Trust (OIT)
- University of Waterloo
- NSERC
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Lewis acid promoted substitution reactions employing Meldrum's acid and 5-methyl Meldrum's acid as carbon-based leaving groups are described which transform unstrained quaternary and tertiary benzylic C-sp3-C-sp3 bonds into C-sp3-X bonds (X = C, H, N). Importantly, this reaction has a broad scope in terms of both suitable substrates and nucleophiles with good to excellent yields obtained (typically >90%).
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