4.8 Article

1,2,3-Triazole: Unique Ligand in Promoting Iron-Catalyzed Propargyl Alcohol Dehydration

Journal

ORGANIC LETTERS
Volume 14, Issue 9, Pages 2358-2361

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol300778e

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Funding

  1. NSF [CHE-0844602]
  2. Direct For Mathematical & Physical Scien [0844602] Funding Source: National Science Foundation
  3. Division Of Chemistry [0844602] Funding Source: National Science Foundation

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A 1,2,3-traizole-promoted Iron(III)-catalyzed propargyl alcohol dehydration was developed for the synthesis of conjugated enynes. The desired conjugated enynes were prepared in good to excellent yields (up to 95%) with a large substrate scope and excellent stereoselectivity (only Z-isomers).

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