Journal
ORGANIC LETTERS
Volume 14, Issue 12, Pages 3020-3023Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol301085v
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Funding
- National Natural Science Foundation of China [21172110, 21121002]
- Tianjin Natural Science Foundation [09JCYBJC05900]
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A hypervalent iodine(III) reagent plays a novel role as an efficient coupling reagent to promote the direct condensation between carboxylic acids and alcohols or amines to provide esters, macrocyclic lactones, amides, as well as peptides without racemization. The regeneration of iodosodilactone (1) can also be readily achieved. The intermediate acyloxyphosphonium ion C from the activation of a carboxylic acid is thought to be involved in the present esterification reaction.
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