4.8 Article

Biomimetic Flavin-Catalyzed Aldehyde Oxidation

Journal

ORGANIC LETTERS
Volume 14, Issue 14, Pages 3656-3659

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol301496m

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Funding

  1. GSK
  2. EPSRC
  3. University of Bath

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The oxidation of alkyl and aryl aldehydes to their corresponding carboxylic acids has been achieved through the action of a biomimetic bridged flavin catalyst. The reaction uses readily available 35% aqueous hydrogen peroxide and is operationally simple. The oxidation is a green and sustainable reaction, obviating chlorinated solvents with minimal byproducts.

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