Journal
ORGANIC LETTERS
Volume 15, Issue 1, Pages 120-123Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol303146a
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Funding
- National Natural Science Foundation [81021062, 20902095]
- Ministry of Science and Technology of P. R. China [2012CB721105]
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Biogenesis inspired chemical investigation of a Chinese folk medicine, Flueggea virosa, returned three unprecedented C,C-linked trimeric Securinega alkaloids, fluevirosines A-C (1-3). Their absolute structures were characterized on the basis of spectroscopic data and computational analysis. Compounds 2 and 3 showed inhibition against the splicing of XBP1 mRNA.
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