Journal
ORGANIC LETTERS
Volume 14, Issue 16, Pages 4102-4105Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol301745b
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Funding
- Natural Science Foundation of Guangdong Province [8351063201000003]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT0965]
- National Natural Science Foundation of China [U0932004]
- China Postdoctoral Science Foundation [201104369]
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Two unusual triterpenes, ilelic acids A (1) and B (2), together with their biosynthetic related compounds ilelic acids C (3) and D (4) were isolated from the leaves of Ilex latifolia. Their structures with absolute configurations were elucidated by spectroscopic analysis and modified Mosher's method. The plausible biogenetic pathway of 1 and 2 is proposed. These triterpenes exhibited a potent inhibitory effect on MCF-7 and MDA-MB-231 cells.
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