Journal
ORGANIC LETTERS
Volume 14, Issue 20, Pages 5362-5365Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol302562a
Keywords
-
Categories
Funding
- National Science Foundation of China [21072190, 21103072]
- Fundamental Research Funds for the Central Universities [21612404]
Ask authors/readers for more resources
An efficient synthesis of 2- or 4-iododibenzofurans through Cul-mediated sequential iodination/cycloetherification of two aromatic C-H bonds in o-arylphenols has been developed. Both the preexisting electron-withdrawing groups (NO2, CN, and CHO) and the newly introduced iodide are readily modified for a focused dibenzofuran library synthesis. Mechanistic studies and DFT calculations suggest that a Cu(III)-mediated rate-limiting C-H activation step is involved in cycloetherification.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available