4.8 Article

Total Synthesis of Incarvilleatone and Incarviditone: Insight into Their Biosynthetic Pathways and Structure Determination

Journal

ORGANIC LETTERS
Volume 14, Issue 18, Pages 4878-4881

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol302205w

Keywords

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Funding

  1. National Science of Foundation of China [21102081, 21133002]
  2. China's 985 project [411307141]
  3. New Teachers' Fund for Doctor Stations, Ministry of Education [20110002120011]
  4. Shenzhen Peacock program

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A concise biomimetic total synthesis of incarvilleatone and incarviditone is achieved in one pot via the highly stereoselective hetero- and homodimerization of (+/-)-rengyolone, respectively. The structure of incarviditone is revised on the basis of spectroscopic and computational evidence.

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